Alport syndrome and thin glomerular basement membrane disease.
نویسندگان
چکیده
منابع مشابه
An Overlapping Case of Alport Syndrome and Thin Basement Membrane Disease
We report a case of a 48-year-old male who presented with hematuria of at least 10 years, and has a daughter with hematuria as well. The patient has a history of degenerative hearing loss, decreased vision and cataract formation, but no diabetes, hypertension or proteinuria. A full serology and urology workup was negative for any abnormality. A kidney biopsy for the patient revealed a diagnosis...
متن کاملClinical and morphological aspects of thin glomerular basement membrane disease.
The report presents the results of investigations carried out in 63 patients (49 children and 14 adults) with thin glomerular basement membrane disease. Of 49 children, 13 came from nine families with family members suffering from kidney diseases (mostly manifested by haematuria). In the group of children, the most frequent initial clinical symptom (noted in 29 cases) was isolated haematuria, m...
متن کاملAnti-Glomerular Basement Membrane Disease.
Anti-glomerular basement membrane (anti-GBM) disease is a rare small vessel vasculitis that affects the capillary beds of the kidneys and lungs. It is an archetypic autoimmune disease, caused by the development of directly pathogenic autoantibodies targeting a well characterized autoantigen expressed in the basement membranes of these organs, although the inciting events that induce the autoimm...
متن کاملMorphological diagnosis of Alport syndrome and thin basement membrane nephropathy by low vacuum scanning electron microscopy.
Alport syndrome (AS) and thin basement membrane nephropathy (TBMN) are genetic disorders caused by mutations of the type IV collagen genes COL4A3, COL4A4, and/or COL4A5. We here aimed to investigate the three-dimensional ultrastructure of the glomerular basement membrane (GBM) in order to introduce a novel method of diagnosing AS and TBMN. The subjects were 4 patients with AS and 6 patients wit...
متن کاملExpert guidelines for the management of Alport syndrome and thin basement membrane nephropathy.
Few prospective, randomized controlled clinical trials address the diagnosis and management of patients with Alport syndrome or thin basement membrane nephropathy. Adult and pediatric nephrologists and geneticists from four continents whose clinical practice focuses on these conditions have developed the following guidelines. The 18 recommendations are based on Level D (Expert opinion without e...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 1998
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v991736